In Fallout: New Vegas, side quests often blend deep narrative elements with meaningful gameplay decisions that shape the Mojave Wasteland. "Guess Who I Saw Today" is a prime example, tasking players with assisting Doctor Henry in Jacobstown as he researches a cure for Nightkin schizophrenia. This walkthrough breaks down every objective and outcome to help players navigate the quest smoothly.

Starting the Quest in Jacobstown

To begin the mission, travel to the peaceful mutant sanctuary of Jacobstown located in the northwest region of Mount Charleston. Head inside the main lodge to find Doctor Henry working in his laboratory alongside his ghoul assistant, Calamity. Speaking with Doctor Henry initiates the quest to investigate stealth-mutated nightstalkers threatening the local area.

Before venturing out, players can optionally recruit Lily Bowen, the Nightkin companion who resides near the lodge. Having Lily in your party provides helpful support while tracking down the source of the mutation.

Exploring Charleston Cave

Your primary field objective requires venturing into Charleston Cave, located just outside of Jacobstown. Navigating through the subterranean tunnels brings you face-to-face with invisible nightstalkers lurking in the dark. Deep within the cavern, players must locate and retrieve a chewed Stealth Boy prototype from a slain nightstalker.

Once the item is secured, return to the Jacobstown lodge to deliver your findings to Doctor Henry. He will ask Lily to participate in an experimental trial using the Mark II prototype.

Confronting Keene and Resolving the Crisis

During the experiment, a hostile Nightkin leader named Keene interrupts the procedure demanding the prototype specifications. Players must resolve this high-tension scenario through combat or diplomacy. Passing a Speech check of 80 allows you to convince Keene to stand down without bloodshed.

Alternatively, players can choose to hand over the prototype data or engage Keene and his followers in direct combat. How you handle Keene plays a significant role in determining the ultimate stability of Jacobstown.

Deciding the Fate of the Nightkin Cure

After resolving the situation with Keene, talk with Doctor Henry to decide how his research should proceed. You can advise him to let Lily continue wearing the Mark II prototype or ask him to halt tests to protect her mental health. Players with a Science skill of 90 can suggest a safer, alternative testing method using nightstalker brains.

Completing this final decision concludes the quest, awarding 500 XP and finalizing the future of the Nightkin cure. Carefully weighing your dialogue choices ensures the best outcome for both Lily and the community of Jacobstown.